Woolly Mouse (CHIP)

The term "woolly mouse" refers to genetically engineered mice developed by Colossal Biosciences to have traits similar to woolly mammoths. These mice have been created as a proof of concept, demonstrating the feasibility of altering genes to produce mammoth-like characteristics. The ultimate goal of this research is to potentially de-extinct the woolly mammoth by engineering similar traits into Asian elephants, the mammoth's closest living relative. 

Here's a more detailed explanation:

Woolly Mouse Creation:

Colossal Biosciences used gene editing techniques to introduce mutations into mice, modeling them after known mammoth genes related to hair growth and fat metabolism. 

Mammoth Traits:

The resulting "woolly mice" have a thicker, woollier coat, and some also exhibit altered fat storage and metabolism, all traits that aided woolly mammoths in surviving cold climates. 

Proof of Concept:

The success in creating these mice demonstrates the potential for gene editing to produce specific traits, a crucial step in the larger project of bringing back the woolly mammoth. 

De-extinction Goal:

While the immediate focus is on engineering Asian elephants with mammoth traits, the woolly mouse project is a key validation step toward the ambitious goal of woolly mammoth de-extinction. 

Scientific Validation:

Some scientists are optimistic about the potential of this research, while others express caution about whether it represents a significant leap towards de-extinction. 

This video explains the creation of woolly mice and their potential to help revive the woolly mammoth: